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Recently, a review of fifty reports involving 43,443 subjects compared the efficacy of the central acting anti-obesity drugs lorcaserin (5HT2c receptor agonist), naltrexone-bupropion (opioid receptor antagonist combined with a norepinephrine releasing agent that stimulates POMC neuronal firing), phentermine-topiramate (a norepinephrine and dopamine modulator plus a carbonate anhydrase inhibitor), and liraglutide

Menopause Weight Gain and GLP-1 Therapy: A Clinical Guide to Hormonal Weight Gain Hormonal imbalance weight gain is a common and frustrating challenge during perimenopause and menopause, especially when changes like perimenopause and irregular periods and stubborn belly fat appear despite healthy habits

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Nutrition Reviews ;71(2):1107